The golden rule of family travel is: Lower your pace expectations. You cannot do 5 museums in a day with a 4-year-old. Plan one major activity in the morning when energy is high, and leave the afternoon open for pools, parks, or naps.
Look for non-stop flights if possible. Layovers extend the travel day and increase meltdown risks. Choose destinations with "kid infrastructure" (sidewalks for strollers, parks, clean water). Japan, Singapore, and Western Europe are excellent.
If you can afford it, buy a seat for your infant (instead of lap infant) for safety and sanity. Time flights around sleep—night flights can work well for long haul if your child sleeps well on planes.
Don't pack diapers for the whole trip—just enough for travel days + 2 days. Buy the rest there. Do pack: essential meds (Tylenol), a change of clothes for YOU (in carry-on in case of spills), and new small toys they haven't seen before.
Finding "kid-friendly" restaurants that aren't just fast food can be tough.
Tell NxVoy AI: "Find me restaurants in Rome near the Colosseum that have high chairs and aren't too quiet." It filters for family amenities instantly.